Eucalyptus oil is well documented as being extremely toxic if ingested. We report a case of systemic eucalyptus oil toxicity from topical application. A 6-year-old girl presented with slurred speech, ataxia and muscle weakness progressing to unconsciousness following the widespread application of a home remedy for urticaria containing eucalyptus oil. Six hours following removal of the topical preparation her symptoms had resolved, with no long term sequelae.