Cardiac amyloidosis, contrictive pericarditis and restrictive cardiomyopathy

Am J Cardiol. 1976 Nov 4;38(5):547-56. doi: 10.1016/s0002-9149(76)80001-x.


Cardiac amyloidosis is not characterized by a single hemodynamic pattern. Some of the cases present the clinical findings of restrictive cardiomyopathy and in these differentiation from constrictive pericarditis remains difficult in spite of the introduction of techniques designed to assess myocardial contractility and ventricular diastolic compliance. The clinical features and the demonstration of left ventricular diastolic pressure greater than right remain the most useful means of distinguishing restrictive cardiomyopathy from constrictive pericarditis. In other cases of cardiac amyloidosis the diastolic pressure is elevated throughout diastole and ventricular ejectile ability is lost. These cases do not simulate constrictive pericarditis and should not be classified as restrictive cardiomyopathy.

MeSH terms

  • Amyloidosis / diagnosis
  • Amyloidosis / physiopathology*
  • Angiocardiography
  • Blood Pressure / drug effects
  • Cardiac Catheterization
  • Cardiac Volume
  • Cardiomyopathies / diagnosis
  • Cardiomyopathies / physiopathology*
  • Compliance
  • Diagnosis, Differential
  • Diuretics / therapeutic use
  • Heart / physiopathology
  • Heart Ventricles / physiopathology
  • Hemodynamics / drug effects
  • Humans
  • Myocardial Contraction / drug effects
  • Pericarditis, Constrictive / diagnosis
  • Pericarditis, Constrictive / physiopathology*


  • Diuretics