Management of recurrent pilocytic astrocytoma with leptomeningeal dissemination in childhood

Childs Nerv Syst. 1998 Nov;14(11):617-22. doi: 10.1007/s003810050286.


Two cases of recurrent pilocytic astrocytoma with leptomeningeal dissemination (LMD) are described. A 6-year-old boy presented with a cerebellar tumor, which was subtotally removed. Tumor recurrence with LMD occurred 4 years later. Reoperation for tumor removal followed by craniospinal irradiation stabilized the LMD over 5 years. A 4-year-old girl presented with a chiasmatic-hypothalamic tumor. Partial removal of the tumor was followed by radiation therapy. Tumor regrowth with LMD occurred 4 years later and was managed by reoperation, chemotherapy and radiotherapy. Tumor recurrence with LMD can be stabilized by multimodal treatment without tumor progression.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Arachnoid / pathology*
  • Astrocytoma / diagnosis
  • Astrocytoma / pathology
  • Astrocytoma / surgery*
  • Cerebellar Neoplasms / diagnosis
  • Cerebellar Neoplasms / pathology
  • Cerebellar Neoplasms / surgery*
  • Child
  • Child, Preschool
  • Combined Modality Therapy
  • Female
  • Humans
  • Hypothalamic Neoplasms / diagnosis
  • Hypothalamic Neoplasms / pathology
  • Hypothalamic Neoplasms / surgery*
  • Magnetic Resonance Imaging
  • Male
  • Neoplasm Recurrence, Local / diagnosis
  • Neoplasm Recurrence, Local / pathology
  • Neoplasm Recurrence, Local / surgery*
  • Optic Chiasm
  • Pia Mater / pathology*