Fatal enterovirus 71 encephalomyelitis

J Pediatr. 1998 Dec;133(6):795-8. doi: 10.1016/s0022-3476(98)70155-6.


During an outbreak of hand-foot-mouth disease caused by enterovirus 71 (EV-71) in 1997, 4 children presented with sudden cardiopulmonary collapse and minimal neurologic features. All children received cardiopulmonary resuscitation but died within a few hours of admission. Postmortem studies showed infection by EV-71 with extensive damage to the medulla and pons. We postulate an etiologic link between EV-71 and brainstem encephalomyelitis as the cause of pulmonary edema and death.

Publication types

  • Case Reports

MeSH terms

  • Child, Preschool
  • Encephalomyelitis / pathology
  • Encephalomyelitis / virology*
  • Enterovirus Infections* / pathology
  • Fatal Outcome
  • Female
  • Humans
  • Infant
  • Male
  • Medulla Oblongata / pathology
  • Pulmonary Edema / virology