Factor V Leiden and prothrombin gene G 20210 A variant in children with ischemic stroke

Thromb Haemost. 1998 Nov;80(5):763-6.


Objective: To investigate if the factor V Leiden mutation (F-V-LM) and/or the prothrombin gene G 20210 A variant (P-G20210A-V) are risk factors for acute stroke in Austrian children.

Patients: 33 children with acute ischemic stroke documented by computer tomography and/or magnetic resonance imaging of the brain were enrolled in an open multicenter survey.

Results: 6/33 children had F-V-LM (5 heterozygous, 1 homozygous). This represents 18% (95% CI: 6.7-39.9%) of our pediatric stroke population and thus exceeds the expected prevalence in the Austrian population of 4,6% (Fischer's exact test, p = 0.01). F-V-LM was not found in 11 children with neonatal stroke but in 6/22 children with stroke after the neonatal period. 5/6 children with F-V-LM had an underlying disorder that is a risk factor for stroke in children. The P-G20210A-V was detected in 1/26 (3.85%; 95% CI: 0.1-21.4%) patients. Comparison of the prevalence of P-G20210A-V in our study with that in the general population of Austria of 1% revealed no statistical significance (Fischer's exact test, p = 0.38).

Conclusion: Our data suggest that the F-V-LM is a risk factor for acute stroke in Austrian children beyond the neonatal period. The P-G20210A-V apparently does not represent a risk factor for stroke in Austrian children.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Activated Protein C Resistance / epidemiology
  • Activated Protein C Resistance / genetics
  • Austria / epidemiology
  • Brain Ischemia / epidemiology
  • Brain Ischemia / genetics*
  • Child
  • Child, Preschool
  • Factor V / genetics*
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Prothrombin / genetics*
  • Regulatory Sequences, Nucleic Acid / genetics*
  • Risk Factors
  • Thrombophilia / epidemiology
  • Thrombophilia / genetics*


  • factor V Leiden
  • Factor V
  • Prothrombin