Vertebrate segmentation: the clock is linked to Notch signalling

Curr Biol. 1998 Dec 3;8(24):R868-71. doi: 10.1016/s0960-9822(07)00547-7.

Abstract

The periodic formation of somites during vertebrate segmentation has been suggested to involve a molecular 'segmentation clock'. Recent observations of cyclic Lunatic fringe expression in chick and mouse embryos link the segmentation clock to Delta-Notch signalling.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Avian Proteins
  • Biological Clocks
  • Body Patterning / genetics
  • Body Patterning / physiology*
  • Chick Embryo
  • Gene Expression Regulation, Developmental
  • Glycosyltransferases*
  • Intracellular Signaling Peptides and Proteins
  • Membrane Proteins / genetics
  • Membrane Proteins / physiology*
  • Mice
  • Proteins / genetics
  • Proteins / physiology
  • Receptors, Notch
  • Signal Transduction
  • Somites / cytology

Substances

  • Avian Proteins
  • Intracellular Signaling Peptides and Proteins
  • Membrane Proteins
  • Proteins
  • Receptors, Notch
  • delta protein
  • Glycosyltransferases
  • LFNG protein, Gallus gallus
  • Lfng protein, mouse