Effect of amantadine on sexual dysfunction in neuroleptic-treated male schizophrenic patients

Clin Neuropharmacol. 1998 Nov-Dec;21(6):355-7.


Twelve male schizophrenic outpatients treated with neuroleptics took part in an open-label drug study to assess the impact of co-administration of amantadine hydrochloride (100 mg daily for 6 weeks) on sexual function. Amantadine improved the patients' scores in three out of four areas of sexual function: desire (p < 0.02), erection (p < 0.05), and satisfaction from sexual performance (p < 0.05); there was no change in ejaculatory function. Amantadine may be effective for improving sexual function in male schizophrenic patients receiving neuroleptic medication.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Amantadine / therapeutic use*
  • Antipsychotic Agents / adverse effects*
  • Antipsychotic Agents / therapeutic use
  • Dopamine Agents / therapeutic use*
  • Humans
  • Male
  • Schizophrenia / complications*
  • Schizophrenia / drug therapy
  • Sexual Dysfunctions, Psychological / chemically induced
  • Sexual Dysfunctions, Psychological / drug therapy*
  • Sexual Dysfunctions, Psychological / etiology


  • Antipsychotic Agents
  • Dopamine Agents
  • Amantadine