Recent improvements of the ProDom database of protein domain families

Nucleic Acids Res. 1999 Jan 1;27(1):263-7. doi: 10.1093/nar/27.1.263.


The ProDom database contains protein domain families generated from the SWISS-PROT database by automated sequence comparisons. The current version was built with a new improved procedure based on recursive PSI-BLAST homology searches. ProDom can be searched on the World Wide Web to study domain arrangements within either known families or new proteins, with the help of a user-friendly graphical interface ( Recent improvements to the ProDom server include: ProDom queries under the SRS Sequence Retrieval System; links to the PredictProtein server; phylogenetic trees and condensed multiple alignments for a better representation of large domain families, with zooming in and out capabilities. In addition, a similar server was set up to display the outcome of whole genome domain analysis as applied to 17 completed microbial genomes ( ).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Databases, Factual*
  • Information Storage and Retrieval
  • Internet
  • Phylogeny
  • Protein Conformation*
  • Proteins / chemistry*
  • Proteins / classification*
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • User-Computer Interface


  • Proteins