Seroprevalence of Helicobacter pylori in a longitudinal study of New Zealanders at ages 11 and 21

Aust N Z J Med. 1998 Oct;28(5):585-9. doi: 10.1111/j.1445-5994.1998.tb00652.x.


Background: Helicobacter pylori seroprevalence increases with age in adult life but spontaneous reversion may occur in childhood and adolescence.

Aims: To determine the seroprevalence of H. pylori in a longitudinal study of New Zealanders at ages 11 and 21.

Methods: Serum from members of the Dunedin Multidisciplinary Health and Development Study (DMHDS) at age 11 (n = 561; 303 males, 258 females) and 21 (n = 785; 413 males, 372 females) was tested for H. pylori antibodies. A large proportion of those tested at age 11 was retested at age 21 (n = 465; 262 males, 203 females). Serological status was examined in terms of gender, socioeconomic status (SES) and self-reported use of antibiotics.

Results: The seroprevalence of H. pylori decreased by 38% from 6.6% (37/561) at age 11 to 4.1% (32/785) at age 21. Seroprevalence at age 11 was not associated with gender or SES. For those tested at both ages, the drop in seroprevalence from 6.7% to 4.1% was statistically significant (t = 2.57, p < 0.01, paired t-test) and was much greater in females (71%) than males (12%). Of the 31 seropositive individuals at age 11, 17 (six males, 11 females) seroreverted and self-reported antibiotic use in the year preceeding age 21 was more common in females (eight/11) than males (zero/six). Of the 434 seronegative individuals at age 11, only five (four males, one female) had seroconverted at age 21.

Conclusions: Seroprevalence in the DMHDS declined from age 11 to 21 predominantly in females. The decline involved a greater rate of seroreversion and lower rate of seroconversion in females than males.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Antibodies, Bacterial / analysis*
  • Child
  • Female
  • Helicobacter Infections / epidemiology*
  • Helicobacter pylori / immunology*
  • Humans
  • Longitudinal Studies
  • Male
  • New Zealand / epidemiology
  • Seroepidemiologic Studies


  • Antibodies, Bacterial