The sarcoglycan complex in limb-girdle muscular dystrophy

Curr Opin Neurol. 1998 Oct;11(5):443-52. doi: 10.1097/00019052-199810000-00006.


The involvement of the sarcoglycan complex in the pathogenesis of muscular dystrophy is becoming increasingly clear. Sarcoglycan gene mutations lead to four forms of autosomal recessive limb-girdle muscular dystrophy. Recent progress has been made with the identification of novel mutations and their correlations with disease. Through this research, a better understanding the molecular pathogenesis of limb-girdle muscular dystrophy has been gained. Finally, animal models are now being used to study viral-mediated gene transfer for the future treatment of this disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cytoskeletal Proteins / genetics*
  • Disease Models, Animal
  • Genetic Therapy
  • Humans
  • Membrane Glycoproteins / genetics*
  • Muscular Dystrophies / etiology
  • Muscular Dystrophies / genetics*
  • Muscular Dystrophies / therapy
  • Mutation


  • Cytoskeletal Proteins
  • Membrane Glycoproteins