Prednisolone plus low-dose aspirin improves the implantation rate in women with autoimmune conditions who are undergoing in vitro fertilization

Fertil Steril. 1998 Dec;70(6):1044-8. doi: 10.1016/s0015-0282(98)00343-4.


Objective: To evaluate the effect of prednisolone plus low-dose aspirin (PSL/LDA) in women with autoimmune conditions who were enrolled in an IVF-ET program.

Design: A retrospective clinical study.

Setting: In vitro fertilization unit, Niigata University Hospital, Niigata, Japan.

Patient(s): Three hundred seven women who underwent IVF-ET between January 1996 and December 1997.

Intervention(s): Prednisolone (10 mg/d) and aspirin (81 mg/d) were administered to the women with autoantibodies who chose to participate.

Main outcome measure(s): Pregnancy and implantation rates with IVF-ET.

Result(s): Women undergoing IVF who had positive antinuclear antibodies, with or without antiphospholipid antibodies, had significantly lower pregnancy and implantation rates than did women without autoantibodies (14.8% versus 21.7% and 6.8% versus 10.4%, respectively). The administration of PSL/LDA to women with antinuclear antibodies significantly improved the outcome of IVF-ET (40.6% pregnancy rate and 20.3% implantation rate).

Conclusion(s): A high proportion of women who are undergoing IVF-ET have autoantibodies, which are associated with poor IVF outcomes. The administration of PSL/LDA to these women may improve their implantation rate.

MeSH terms

  • Adult
  • Antibodies, Antinuclear / blood
  • Antibodies, Antiphospholipid / blood
  • Aspirin / therapeutic use*
  • Autoimmune Diseases / drug therapy*
  • Dose-Response Relationship, Drug
  • Drug Therapy, Combination
  • Embryo Implantation*
  • Embryo Transfer*
  • Female
  • Fertilization in Vitro*
  • Humans
  • Prednisolone / therapeutic use*
  • Pregnancy
  • Pregnancy Rate*
  • Retrospective Studies


  • Antibodies, Antinuclear
  • Antibodies, Antiphospholipid
  • Prednisolone
  • Aspirin