Parvovirus B19 is an ubiquitous organism. Although for many years it had been "a virus in search of a disease," it is now known to be associated with several clinical entities ranging from the benign to severe. The most significant aspect of parvovirus B19 is its effect on the fetus. Research has demonstrated the risk, although minimal, of fetal loss to be between 1.5% to 2.5%. The effect from an emotional standpoint for the pregnant exposed or infected woman is more difficult to quantify. It is imperative that nurses who care for children be well informed about the virus and able to implement a comprehensive plan.