Abstract
Denervation of skeletal muscle results in rapid atrophy with loss of contractile mass and/or progressive degeneration of muscle fibers which are replaced to a greater or lesser degree by connective and fatty tissues. In this study, we show that denervated rabbit muscles are transformed into a white adipose tissue, depending on their fiber types. This tissue does express LPL, G3PDH and particularly the ob gene, a white adipose tissue-specific marker, and does not express the brown adipose tissue molecular marker UCP1 mRNA.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adipose Tissue / enzymology
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Adipose Tissue / innervation*
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Adipose Tissue / metabolism
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Adipose Tissue / pathology*
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Animals
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Biomarkers
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Glycerolphosphate Dehydrogenase / metabolism
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Leptin
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Lipoprotein Lipase / metabolism
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Muscle Denervation*
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Muscle Fibers, Skeletal / physiology
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Muscle, Skeletal / innervation*
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Muscle, Skeletal / metabolism
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Muscle, Skeletal / pathology
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Myogenin / metabolism
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Proteins / metabolism*
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RNA, Messenger / metabolism
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Rabbits
Substances
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Biomarkers
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Leptin
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Myogenin
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Proteins
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RNA, Messenger
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Glycerolphosphate Dehydrogenase
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Lipoprotein Lipase