Möbius' syndrome: features and etiology

J Pediatr Ophthalmol Strabismus. Nov-Dec 1998;35(6):304-11; quiz 327-8.


Purpose: To review the clinical features and possible aetiology of all cases of Möbius' syndrome presented at the Royal Alexandra Hospital for Children in Sydney, Australia, from 1963 through 1995.

Methods: All charts of patients suffering from Möbius' syndrome were reviewed, and each patient was thoroughly assessed by a geneticist and a pediatric ophthalmologist.

Results: Patterns of systemic and ocular clinical features became evident. Of 23 patients in the series, 10 (43%) had a history significant events in utero.

Conclusions: All patients suffering from Möbius' syndrome require thorough assessment by a multidisciplinary team including a geneticist or pediatrician and a pediatric ophthalmologist. Significant vascular events of pregnancy may explain some cases of fetal vascular disruption to the brainstem.

MeSH terms

  • Abducens Nerve / pathology
  • Animals
  • Cranial Nerve Diseases / congenital
  • Cranial Nerve Diseases / pathology
  • Craniofacial Abnormalities / complications
  • Facial Nerve / pathology
  • Facial Paralysis / etiology*
  • Facial Paralysis / pathology*
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Limb Deformities, Congenital / complications
  • Male
  • Paralysis / congenital
  • Paralysis / pathology
  • Pregnancy
  • Pregnancy Complications / etiology
  • Rats