Does NADH play a central role in energy metabolism in Helicobacter pylori?

M Finel

doi:10.1016/s0968-0004(98)01276-6

Does NADH play a central role in energy metabolism in Helicobacter pylori?

Trends Biochem Sci. 1998 Nov;23(11):412-3. doi: 10.1016/s0968-0004(98)01276-6.

Author

M Finel¹

Affiliation

¹ Dept of Medical Chemistry, University of Helsinki, Finland.

PMID: 9852756
DOI: 10.1016/s0968-0004(98)01276-6

Abstract

The complete genome sequence of Helicobacter pylori reveals an unusual NADH-quinone oxidoreductase (NDH-1 or Complex I) that might lack the NADH-binding domain. H. pylori also lacks various NADH-generating enzymes. What are the consequences for electron transfer to H. pylori NDH-1 and could NADPH be involved?

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Amino Acid Sequence
Binding Sites
Energy Metabolism / physiology*
Helicobacter pylori / physiology*
Molecular Sequence Data
NAD / physiology*
NAD(P)H Dehydrogenase (Quinone) / genetics
NAD(P)H Dehydrogenase (Quinone) / metabolism
Operon
Sequence Alignment
Sequence Homology, Amino Acid

Substances

NAD
NAD(P)H Dehydrogenase (Quinone)

Associated data

GENBANK/AE000631
GENBANK/P76489
GENBANK/Q46508
GENBANK/Q56223