Angiogenesis and apoptosis are cellular parameters of neoplastic progression in transgenic mouse models of tumorigenesis

Int J Dev Biol. 1998;42(7):995-1002.

Abstract

The epidemiology and histopathology of human cancers and studies of animal models of tumorigenesis have led to a widely-accepted notion that multiple genetic and epigenetic changes have to accrue for the successful development of a malignant phenotype. Tumor growth and expansion requires an ability not only to proliferate, but also to down-modulate cell death (apoptosis) and activate angiogenesis to produce a tumor neovasculature. This review will describe the interplay between apoptosis and proliferation, as well as the characteristics of the angiogenic phenotype in two transgenic mouse models of multi-step tumorigenesis, namely, pancreatic islet cell carcinomas and squamous cell carcinomas of the skin.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Apoptosis / physiology*
  • Cell Division
  • Cell Transformation, Neoplastic*
  • Disease Models, Animal
  • Disease Progression
  • Humans
  • Mice
  • Mice, Knockout
  • Mice, Transgenic
  • Neoplasms / pathology
  • Neoplasms / physiopathology*
  • Neoplasms, Experimental / pathology
  • Neoplasms, Experimental / physiopathology
  • Neovascularization, Pathologic*