The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease

Trends Cell Biol. 1998 Nov;8(11):447-53. doi: 10.1016/s0962-8924(98)01363-4.


It is a truism of modern biomedical science that the development of therapies expected to slow or arrest the progression of a disease requires as detailed an understanding of its molecular and cellular pathogenesis as possible. In turn, the cloning of novel gene products implicated in a disease often leads to new insights about fundamental features of protein structure and function. A particularly compelling example of this beneficial interplay between basic and applied cell biology arises from the exciting recent progress in deciphering Alzheimer's disease (AD). This review discusses the current understanding of the cell biology of two proteins crucial for the pathogenesis of AD, the beta-amyloid precursor protein and presenilin.

Publication types

  • Review

MeSH terms

  • Alzheimer Disease / metabolism*
  • Alzheimer Disease / physiopathology
  • Amyloid Precursor Protein Secretases
  • Amyloid beta-Peptides / biosynthesis
  • Amyloid beta-Protein Precursor / metabolism*
  • Animals
  • Aspartic Acid Endopeptidases
  • Biological Transport
  • Endopeptidases / metabolism
  • Humans
  • Membrane Proteins / metabolism*
  • Neurons
  • Presenilin-2
  • Protein Processing, Post-Translational
  • Subcellular Fractions


  • Amyloid beta-Peptides
  • Amyloid beta-Protein Precursor
  • Membrane Proteins
  • PSEN2 protein, human
  • Presenilin-2
  • Amyloid Precursor Protein Secretases
  • Endopeptidases
  • Aspartic Acid Endopeptidases
  • BACE1 protein, human