[The pharmacokinetics and metabolism of heptapeptide--a prospective synthetic analog of tuftsin with psychostimulating action in rats]

Eksp Klin Farmakol. 1998 Sep-Oct;61(5):42-5.
[Article in Russian]

Abstract

The pharmacokinetics of a new heptapeptide with psychotropic activity was studied in rats in experiments in vitro and in vivo by means of high-performance liquid chromatography. The heptapeptide was detected in its natural form in rat blood plasma for 7-10 min; its T1/2 exceeded that of other oligopeptides of similar structure. The structure of the main pharmacologically active heptapeptide metabolite was identified by high performance liquid chromatography; it proved to be tetrapeptide Thr-Lys-Pro-Arg (taphtsin). The heptapeptide was distributed in well vascularized organs of rats: liver > kidneys > heart.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Chromatography, High Pressure Liquid
  • Half-Life
  • Psychotropic Drugs / analysis
  • Psychotropic Drugs / pharmacokinetics*
  • Rats
  • Time Factors
  • Tissue Distribution
  • Tuftsin / analogs & derivatives*
  • Tuftsin / analysis
  • Tuftsin / pharmacokinetics*

Substances

  • Psychotropic Drugs
  • Tuftsin