Analysis of epitope spreading over an eleven-year period in a patient with systemic lupus erythematosus

Scand J Rheumatol. 1998;27(6):461-4. doi: 10.1080/030097498442316.


During a period of more than eleven years serum samples of a patient with Systemic Lupus Erythematosus were collected and analyzed for anti-nuclear autoantibodies. High titer of anti-La/SS-B were detectable in all serum samples. The La/SS-B epitopes remained constant. Besides anti-La/SS-B antibodies all serum samples contained traces of anti-Ro/SS-A including anti-Ro52 and anti-Ro60 antibodies. During disease flares anti-Ro/SS A antibodies were upregulated and anti-dsDNA antibodies appeared, thus supporting the concept of an antigen driven intermolecular epitope spreading to Ro/SS-A and dsDNA.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antibodies, Antinuclear / analysis
  • Antibodies, Antinuclear / immunology*
  • Epitope Mapping*
  • Epitopes / immunology*
  • Female
  • Humans
  • Lupus Erythematosus, Systemic / immunology*


  • Antibodies, Antinuclear
  • Epitopes
  • SS-A antibodies
  • SS-B antibodies