Different time courses of recovery after poisoning with botulinum neurotoxin serotypes A and E in humans

Neurosci Lett. 1998 Nov 13;256(3):135-8. doi: 10.1016/s0304-3940(98)00775-7.

Abstract

Botulinum toxin serotypes A and E (BoNT/A and /E) cleave the carboxy-terminus of synaptosomal associated protein-25 (SNAP-25) removing nine and 26 residues, respectively. To investigate the effect of these lesions of the same target molecule, 11 volunteers were injected with 3 IU of BoNT/A in the extensor digitorum brevis (EDB) muscle of one foot and with 3 IU of BoNT/E in the contralateral one. In addition, seven volunteers were similarly injected with mixtures of BoNT/A + BoNT/E. Compound muscular action potential (CMAP) was measured at different time intervals and the percentage variation of CMAP (%CMAP) was calculated. Unexpectedly, a much faster recovery of %CMAP after BoNT/E injections was observed. Double poisoned EBD muscles recovered similarly to BoNT/E. So, a larger deletion of the SNAP-25 molecule caused by BoNT/E leads to a faster functional recovery.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials / drug effects
  • Adult
  • Aged
  • Botulinum Toxins / administration & dosage
  • Botulinum Toxins / therapeutic use*
  • Botulinum Toxins, Type A / administration & dosage
  • Botulinum Toxins, Type A / therapeutic use*
  • Drug Synergism
  • Dystonia / drug therapy*
  • Electric Stimulation
  • Female
  • Foot / physiology
  • Humans
  • Injections, Intramuscular
  • Male
  • Middle Aged
  • Muscle, Skeletal / drug effects*
  • Muscle, Skeletal / innervation
  • Muscle, Skeletal / physiology
  • Neuromuscular Junction / drug effects
  • Neuromuscular Junction / physiology
  • Time Factors

Substances

  • Botulinum Toxins
  • Botulinum Toxins, Type A
  • botulinum toxin type E

Grant support