Hyperphagia in pre-fed rats following oral delta9-THC

Physiol Behav. 1998 Nov 15;65(2):343-6. doi: 10.1016/s0031-9384(98)00170-x.


Using a pre-feed paradigm, the effects of orally-administered delta9-tetrahydrocannabinol (THC) on low baseline levels of nocturnal feeding were assessed. Following 2-h access to a palatable wet mash diet at dark onset, adult male Lister hooded rats (Charles River) were treated with either sesame seed oil vehicle or delta9- tetrahydrocannabinol (0.063, 0.12, 0.25, 0.5, 1.0, or 2.0 mg/kg). One hour later, rats were allowed ad libitum access to standard chow, and intakes were monitored over the subsequent 24 h. Doses of 0.5, 1.0, and 2.0 mg/kg produced substantial hyperphagia during the first hour of testing. Subsequently, rats compensated for their overconsumption so that 24-h intakes were similar in all conditions. The data confirm anecdotal reports of the orexigenic actions of exogenous cannabinoids and suggest a critical role for endogenous cannabinoid systems in the regulation of appetite.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Animals
  • Appetite Stimulants / pharmacology*
  • Dose-Response Relationship, Drug
  • Dronabinol / pharmacology*
  • Eating / drug effects
  • Hyperphagia / chemically induced*
  • Male
  • Rats
  • Time Factors


  • Appetite Stimulants
  • Dronabinol