[Writer's cramp treated with botulinum injections]

Ned Tijdschr Geneeskd. 1998 Aug 1;142(31):1768-71.
[Article in Dutch]


Objective: To evaluate the first clinical experience with local botulinum toxin A (BTA) injections in patients with writer's cramp.

Design: Descriptive.

Setting: Academic Medical Centre, Amsterdam, the Netherlands.

Method: In May 1993-January 1996 ten patients with writer's cramp were treated with BTA (Dysport). Age of the patients varied from 28 to 68 years, the duration of complaints from 1 to 29 years. Muscles for injections were selected by observation, sometimes combined with electromyography. BTA was administered under electromyographic guidance.

Results: The amount of BTA administered per treatment session ranged from 15 to 400 IU. In three patients the BTA-induced weakness necessary to reach a beneficial effect on writing was unacceptable. In seven patients the response was satisfactory or good and lasted 2 to 15 months (mean: 3.5 months).

Conclusion: The results confirm the efficacy of BTA in writer's cramp.

Publication types

  • Clinical Trial
  • English Abstract

MeSH terms

  • Adult
  • Aged
  • Botulinum Toxins, Type A / adverse effects
  • Botulinum Toxins, Type A / therapeutic use*
  • Electromyography / methods
  • Female
  • Hand
  • Handwriting*
  • Humans
  • Injections, Intramuscular
  • Male
  • Middle Aged
  • Muscle Cramp / drug therapy*
  • Muscle Weakness / chemically induced
  • Neuromuscular Agents / adverse effects
  • Neuromuscular Agents / therapeutic use*
  • Treatment Outcome


  • Neuromuscular Agents
  • Botulinum Toxins, Type A