Chronic gastric ulcer in the rat produced by wounding at the fundo-antral junction

Gastroenterology. 1976 Sep;71(3):416-20.


Standardized 8-mm mucosal wounds were made in the rat stomach at the rumeno-fundic junction, fundus, fundo-antral junction, and antrum, and examined at intervals up to 8 months. All wounds at the rumeno-fundic junction and fundus were healed within 4 weeks and at the antrum within 12 weeks. The majority of wounds at the fundo-antral junction remained chronic and at 8 months 41 of 50 rats still had ulcers 2 mm or greater in diameter. These findings suggest that the fundo-antral junction is an area which is susceptible to the development of chronic ulcers. This is a simple and reliable method of producing chronic gastric ulcers and does not alter the continuity or disturb the function of the gastrointestinal tract.

MeSH terms

  • Animals
  • Cell Movement
  • Chronic Disease
  • Epithelial Cells
  • Epithelium / ultrastructure
  • Female
  • Gastric Mucosa / injuries
  • Gastric Mucosa / pathology
  • Humans
  • Pyloric Antrum / injuries*
  • Rats
  • Stomach Ulcer / etiology*
  • Stomach Ulcer / pathology
  • Time Factors
  • Wound Healing
  • Wounds and Injuries / complications