Association between anxiety disorders and a functional polymorphism in the serotonin transporter gene

Psychiatry Res. 1998 Nov 16;81(2):277-9. doi: 10.1016/s0165-1781(98)00100-0.


Recently, individuals with the short form of the serotonin transporter were found to be associated with neurotic characteristics. An association study on this polymorphism was performed in anxiety disorder patients and control subjects. The short form allele frequency in patients tended to be higher than that in control subjects (81.7 vs. 74.5%). Although it is difficult to ascribe significance to these 'tendencies', these data may suggest that variation of this functional polymorphism makes some contribution to anxiety disorders.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alleles
  • Anxiety Disorders / diagnosis
  • Anxiety Disorders / genetics*
  • Carrier Proteins / genetics*
  • Female
  • Gene Frequency / genetics
  • Genetic Predisposition to Disease / genetics
  • Humans
  • Male
  • Membrane Glycoproteins / genetics*
  • Membrane Transport Proteins*
  • Middle Aged
  • Nerve Tissue Proteins*
  • Polymorphism, Genetic / genetics*
  • Serotonin Plasma Membrane Transport Proteins


  • Carrier Proteins
  • Membrane Glycoproteins
  • Membrane Transport Proteins
  • Nerve Tissue Proteins
  • SLC6A4 protein, human
  • Serotonin Plasma Membrane Transport Proteins