1H MR spectroscopy monitoring of changes in choline peak area and line shape after Gd-contrast administration

Magn Reson Imaging. 1998 Dec;16(10):1273-80. doi: 10.1016/s0730-725x(98)00143-x.

Abstract

Fifteen percent loss in the peak area of choline containing compounds (Cho) was recently observed in 1H MR spectra of contrast-enhancing tumor at 5-10 min after Gd-contrast administration [Magn. Reson. Med. 37:222-225, 1997]. In this study, chemical shift imaging (CSI, 1500/135 ms PRESS) was used to assess the spectral changes in 47 Gd-enhancing glial brain tumors and metastatic brain tumors measured at 0-5, 5-10, and/or 10-15 min after administration of Gd-contrast. Percent Cho peak area losses measured at these times, 3 +/- 3, 12 +/- 2, and 14 +/- 3 SEM, respectively, coincided with trends of line narrowing and up-field shift of the Cho peak. Significant changes in creatine and N-acetyl acetate signals were not observed. It is concluded that the Gd-induced loss of tumor Cho signal measured after 5 min, typically required for post contrast-MRI and the positioning of the CSI volume on tumor, shows little further change with time, if any.

MeSH terms

  • Adult
  • Aged
  • Brain / metabolism*
  • Brain / pathology
  • Brain Neoplasms / diagnosis
  • Brain Neoplasms / metabolism
  • Brain Neoplasms / secondary
  • Choline / metabolism*
  • Contrast Media*
  • Female
  • Gadolinium DTPA*
  • Glioma / diagnosis
  • Glioma / metabolism
  • Glioma / secondary
  • Humans
  • Magnetic Resonance Imaging / instrumentation
  • Magnetic Resonance Imaging / methods
  • Magnetic Resonance Imaging / statistics & numerical data
  • Magnetic Resonance Spectroscopy / instrumentation
  • Magnetic Resonance Spectroscopy / methods*
  • Male
  • Middle Aged
  • Normal Distribution
  • Time Factors

Substances

  • Contrast Media
  • Gadolinium DTPA
  • Choline