Short CAG repeats within the hSKCa3 gene associated with schizophrenia: results of a family-based study

Neuroreport. 1998 Nov 16;9(16):3595-9. doi: 10.1097/00001756-199811160-00010.


In a family-based association study we investigated transmission of a multiallelic CAG repeat in a novel neuronal potassium channel gene, hSKCa3, in 59 parent/ offspring trios. In contrast to recent reports of an association of moderately large repeats with schizophrenia in case-control studies, our findings indicate that short CAG repeats (< or=19 repeats) are transmitted at an increased frequency to schizophrenic offspring (p=0.014), particularly among familial cases (p=0.007). No evidence for a parent-of-origin effect was found. Multiallelic TDT procedure showed no association of individual CAG repeats to schizophrenia. Further studies using family-based designs should clarify whether hSKCa3 is a susceptibility factor to schizophrenia or co-segregates with a major disease gene in tight linkage.

MeSH terms

  • Adolescent
  • Adult
  • Alleles
  • DNA Mutational Analysis
  • Family Health*
  • Female
  • Genetic Linkage
  • Genotype
  • Humans
  • Male
  • Neuropeptides / genetics*
  • Pedigree
  • Polymorphism, Genetic
  • Potassium Channels / genetics*
  • Schizophrenia / genetics*
  • Small-Conductance Calcium-Activated Potassium Channels
  • Trinucleotide Repeats*


  • KCNN3 protein, human
  • Neuropeptides
  • Potassium Channels
  • Small-Conductance Calcium-Activated Potassium Channels