Why cholesterol as a central theme in coronary artery disease?

Am J Cardiol. 1998 Nov 26;82(10B):14T-17T. doi: 10.1016/s0002-9149(98)00717-6.


Evidence from epidemiologic studies and clinical trials have conclusively demonstrated a direct association between coronary artery disease and levels of total and low-density lipoprotein (LDL) cholesterol. Data from a number of studies suggest that even "average" or "normal" cholesterol levels are too high with respect to coronary artery disease risk. Low levels of high-density lipoprotein (HDL) cholesterol have also emerged as a coronary artery disease risk. A recent meta-analysis has eliminated much of the controversy surrounding triglyceride's contribution to coronary artery disease risk, establishing triglyceride levels as an independent risk factor. Lowering lipid levels by any means-including pharmacologic, surgical, and dietary/lifestyle changes--decreases coronary artery disease risk.

Publication types

  • Review

MeSH terms

  • Aged
  • Anticholesteremic Agents / therapeutic use*
  • Cholesterol, LDL / blood*
  • Clinical Trials as Topic
  • Coronary Disease / diet therapy
  • Coronary Disease / etiology
  • Coronary Disease / prevention & control*
  • Diet, Fat-Restricted
  • Dietary Fats, Unsaturated / administration & dosage*
  • Female
  • Humans
  • Male
  • Middle Aged


  • Anticholesteremic Agents
  • Cholesterol, LDL
  • Dietary Fats, Unsaturated