Structure-function of cytochromes P450 and flavin-containing monooxygenases: implications for drug metabolism

Drug Metab Dispos. 1998 Dec;26(12):1223-31.


This article is a report on a symposium held at Experimental Biology '98 in San Francisco, California. Recent developments in site-directed mutagenesis, computer-modeling, and mechanistic analysis of cytochromes P450 and flavin-containing monooxygenases are described. A unifying theme is the elaboration of general approaches for understanding and predicting the function of individual forms of these enzymes. A related goal is the production of soluble forms of mammalian cytochromes P450 for X-ray crystallography.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cytochrome P-450 Enzyme System / chemistry
  • Cytochrome P-450 Enzyme System / metabolism*
  • Flavins / metabolism*
  • Humans
  • Mixed Function Oxygenases / metabolism*
  • Pharmaceutical Preparations / metabolism*
  • Structure-Activity Relationship


  • Flavins
  • Pharmaceutical Preparations
  • Cytochrome P-450 Enzyme System
  • Mixed Function Oxygenases