Reversible impairment of renal function associated with enalapril in a diabetic patient

CMAJ. 1998 Nov 17;159(10):1279-81.


Acute renal failure and hyperkalemia due to angiotensin-converting enzyme inhibitors have been described in diabetic patients with other predisposing conditions. The case reported here involves a patient with type 1 diabetes mellitus, microalbuminuria and normal renal function who was treated with enalapril. Two years after initiation of this therapy, at a time when glycemic control was poor, he presented with symptomatic hyperkalemia and impaired renal function accompanied by hyporeninemic hypoaldosteronism. This case illustrates that reversible impairment of renal function and hyperkalemia can present after 2 years of treatment with angiotensin-converting enzyme inhibitors in patients with precipitating factors.

Publication types

  • Case Reports

MeSH terms

  • Acute Kidney Injury / chemically induced*
  • Adult
  • Angiotensin-Converting Enzyme Inhibitors / adverse effects*
  • Antihypertensive Agents / adverse effects*
  • Diabetes Mellitus, Type 1 / complications*
  • Diabetic Nephropathies / complications*
  • Enalapril / adverse effects*
  • Humans
  • Hyperkalemia / chemically induced
  • Hypertension / complications
  • Hypertension / drug therapy*
  • Hypoaldosteronism / chemically induced
  • Male
  • Precipitating Factors


  • Angiotensin-Converting Enzyme Inhibitors
  • Antihypertensive Agents
  • Enalapril