Nuclear migration, nucleokinesis and lissencephaly

Trends Cell Biol. 1998 Dec;8(12):467-70. doi: 10.1016/s0962-8924(98)01389-0.


During the past 20 years, biologists have become used to finding that proteins first identified in simple, genetically manipulable eukaryotic organisms are conserved in higher eukaryotes. This article draws attention to the similarity between NUDF protein, which is required for nuclear migration in the filamentous fungus Aspergillus nidulans, and a mammalian homologue, LIS1, whose malfunction causes lissencephaly, a neuronal migration disease. The authors suggest that there might be an underlying similarity of mechanism between nuclear migration in the fungus and neuronal migration in the brain.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Movement
  • Cell Nucleus / physiology*
  • Fungal Proteins / metabolism*
  • Microtubule-Associated Proteins*
  • Neurons / physiology
  • Proteins / metabolism*


  • Fungal Proteins
  • Microtubule-Associated Proteins
  • NUDC protein, Emericella nidulans
  • NUDF protein, Emericella nidulans
  • Proteins