Anti-HIV-1 and anti-HIV-1-protease Substances From Ganoderma Lucidum

Phytochemistry. 1998 Nov;49(6):1651-7. doi: 10.1016/s0031-9422(98)00254-4.

Abstract

A new highly oxygenated triterpene named ganoderic acid alpha has been isolated from a methanol extract of the fruiting bodies of Ganoderma lucidum together with twelve known compounds. The structures of the isolated compounds were determined by spectroscopic means including 2D-NMR. Ganoderiol F and ganodermanontriol were found to be active as anti-HIV-1 agents with an inhibitory concentration of 7.8 micrograms ml-1 for both, and ganoderic acid B, ganoderiol B, ganoderic acid C1, 3 beta-5 alpha-dihydroxy-6 beta-methoxyergosta-7,22-diene, ganoderic acid alpha, ganoderic acid H and ganoderiol A were moderately active inhibitors against HIV-1 PR with a 50% inhibitory concentration of 0.17-0.23 mM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-HIV Agents / chemistry
  • Anti-HIV Agents / isolation & purification*
  • Anti-HIV Agents / pharmacology
  • Cell Line
  • Cytopathogenic Effect, Viral / drug effects
  • Drugs, Chinese Herbal / pharmacology*
  • HIV Protease Inhibitors / chemistry
  • HIV Protease Inhibitors / isolation & purification*
  • HIV Protease Inhibitors / pharmacology
  • HIV-1 / drug effects
  • HIV-1 / pathogenicity
  • Humans
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Medicine, Chinese Traditional
  • Plants, Medicinal / chemistry*
  • Reverse Transcriptase Inhibitors / chemistry
  • Reverse Transcriptase Inhibitors / isolation & purification
  • Reverse Transcriptase Inhibitors / pharmacology

Substances

  • Anti-HIV Agents
  • Drugs, Chinese Herbal
  • HIV Protease Inhibitors
  • Reverse Transcriptase Inhibitors