Low Serum Carotene Level and Increased Risk of Ischemic Heart Disease Related to Long-Term Arsenic Exposure

Atherosclerosis. 1998 Dec;141(2):249-57. doi: 10.1016/s0021-9150(98)00178-6.

Abstract

To elucidate the association between arsenic-related ischemic heart disease (ISHD) and serum antioxidant micronutrient level, residents aged 30 or older living in arseniasis-hyperendemic villages in Taiwan were recruited in a community-based health survey. A structured questionnaire was used to obtain a history of long-term exposure to arsenic through consuming artesian well water and fasting serum samples were also collected at the recruitment. A total of 74 patients affected with ISHD, who were diagnosed through both electrocardiography and Rose questionnaire interview, and 193 age-sex-matched healthy controls were selected for the examination of serum levels of micronutrients by high performance liquid chromatography (HPLC). There was a significant biological gradient between the risk of ISHD and the duration of consuming high-arsenic artesian well water. A significant reverse dose-response relationship with arsenic-related ISHD was observed for serum level of alpha- and beta-carotene, but not for serum levels of retinol, lycopene and alpha-tocopherol. Multivariate analysis showed a synergistic interaction on arsenic-related ISHD between duration of consuming artesian well water and low serum carotene level. An increased risk of arsenic-related ISHD was also associated with hypertension and elevated body mass index, but not with serum lipid profile, cigarette smoking and alcohol drinking. The findings seem to suggest that arsenic-related ISHD has a pathogenic mechanism which is at least partially different from that of ISHD unrelated to long-term exposure to arsenic.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alcohol Drinking
  • Antioxidants / metabolism*
  • Arsenic / adverse effects*
  • Carotenoids / blood*
  • Chromatography, High Pressure Liquid
  • Humans
  • Lycopene
  • Multivariate Analysis
  • Myocardial Ischemia / blood*
  • Myocardial Ischemia / chemically induced*
  • Myocardial Ischemia / epidemiology
  • Risk Factors
  • Smoking
  • Socioeconomic Factors
  • Surveys and Questionnaires
  • Taiwan / epidemiology
  • Time Factors
  • Vitamin A / blood
  • Vitamin E / blood
  • Water Supply* / analysis
  • beta Carotene / blood

Substances

  • Antioxidants
  • beta Carotene
  • Vitamin A
  • Vitamin E
  • Carotenoids
  • alpha-carotene
  • Arsenic
  • Lycopene