Intensive lifestyle changes for reversal of coronary heart disease

JAMA. 1998 Dec 16;280(23):2001-7. doi: 10.1001/jama.280.23.2001.

Abstract

Context: The Lifestyle Heart Trial demonstrated that intensive lifestyle changes may lead to regression of coronary atherosclerosis after 1 year.

Objectives: To determine the feasibility of patients to sustain intensive lifestyle changes for a total of 5 years and the effects of these lifestyle changes (without lipid-lowering drugs) on coronary heart disease.

Design: Randomized controlled trial conducted from 1986 to 1992 using a randomized invitational design.

Patients: Forty-eight patients with moderate to severe coronary heart disease were randomized to an intensive lifestyle change group or to a usual-care control group, and 35 completed the 5-year follow-up quantitative coronary arteriography.

Setting: Two tertiary care university medical centers.

Intervention: Intensive lifestyle changes (10% fat whole foods vegetarian diet, aerobic exercise, stress management training, smoking cessation, group psychosocial support) for 5 years.

Main outcome measures: Adherence to intensive lifestyle changes, changes in coronary artery percent diameter stenosis, and cardiac events.

Results: Experimental group patients (20 [71%] of 28 patients completed 5-year follow-up) made and maintained comprehensive lifestyle changes for 5 years, whereas control group patients (15 [75%] of 20 patients completed 5-year follow-up) made more moderate changes. In the experimental group, the average percent diameter stenosis at baseline decreased 1.75 absolute percentage points after 1 year (a 4.5% relative improvement) and by 3.1 absolute percentage points after 5 years (a 7.9% relative improvement). In contrast, the average percent diameter stenosis in the control group increased by 2.3 percentage points after 1 year (a 5.4% relative worsening) and by 11.8 percentage points after 5 years (a 27.7% relative worsening) (P=.001 between groups. Twenty-five cardiac events occurred in 28 experimental group patients vs 45 events in 20 control group patients during the 5-year follow-up (risk ratio for any event for the control group, 2.47 [95% confidence interval, 1.48-4.20]).

Conclusions: More regression of coronary atherosclerosis occurred after 5 years than after 1 year in the experimental group. In contrast, in the control group, coronary atherosclerosis continued to progress and more than twice as many cardiac events occurred.

Publication types

  • Clinical Trial
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Angina Pectoris
  • Coronary Angiography
  • Coronary Artery Disease / prevention & control
  • Coronary Disease / diagnosis
  • Coronary Disease / epidemiology
  • Coronary Disease / physiopathology
  • Coronary Disease / prevention & control*
  • Diet
  • Disease Progression
  • Exercise
  • Feasibility Studies
  • Female
  • Health Behavior*
  • Humans
  • Life Style*
  • Lipids / blood
  • Male
  • Middle Aged
  • Risk Factors
  • Self-Help Groups
  • Smoking Cessation
  • Stress, Psychological / prevention & control
  • Time Factors

Substances

  • Lipids