Adverse drug reactions leading to hospitalization in children

J Pediatr. 1976 Sep;89(3):487-90. doi: 10.1016/s0022-3476(76)80560-4.

Abstract

During a three-year period of prospective epidemiologic surveillance for adverse drug reactions in a pediatric population, 72 (2.0%) of 3,556 medical admissions were the result of adverse drug reactions. Antineoplastic drugs were most frequently cited as causing a reaction leading to admission. Approximately 40% of the reactions were severe, and four reactions contributed to death.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adolescent
  • Anemia, Aplastic / chemically induced
  • Antineoplastic Agents / adverse effects
  • Bone Marrow Diseases / chemically induced*
  • Child
  • Child, Hospitalized
  • Child, Preschool
  • Digitalis Glycosides / poisoning
  • Drug-Related Side Effects and Adverse Reactions*
  • Female
  • Florida
  • Hospitalization*
  • Humans
  • Iatrogenic Disease
  • Infant
  • Male
  • Retrospective Studies
  • Thrombocythemia, Essential / chemically induced

Substances

  • Antineoplastic Agents
  • Digitalis Glycosides