Prospective study of nonsteroidal anti-inflammatory drugs and breast cancer

Oncol Rep. Jan-Feb 1999;6(1):71-3.

Abstract

We conducted a prospective cohort study of Nonsteroidal anti-inflammatory drugs (NSAIDs) and breast cancer among 32,505 women in central Ohio, USA. After 5 years of follow-up, a total of 393 cases have been detected. The annual incidence of breast cancer per 100,00 women varied inversely with increasing intake of NSAIDs, declining from 323 among non-users to 183 among heavy users (p<0.01). Breast cancer rates decreased by about 50% with regular ibuprofen intake (p<0.01), and by about 40% with regular aspirin intake (p<0.05). The results suggest that specific NSAIDs may be effective chemopreventive agents against breast cancer.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acetaminophen / therapeutic use*
  • Adult
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Anticarcinogenic Agents / therapeutic use*
  • Aspirin / therapeutic use*
  • Body Mass Index
  • Breast Neoplasms / epidemiology
  • Breast Neoplasms / prevention & control*
  • Estrogen Replacement Therapy
  • Female
  • Follow-Up Studies
  • Humans
  • Ibuprofen / therapeutic use*
  • Incidence
  • Ohio / epidemiology
  • Prospective Studies
  • Risk Factors

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Anticarcinogenic Agents
  • Acetaminophen
  • Aspirin
  • Ibuprofen