Chloroquine inhibits HIV-1 replication in human peripheral blood lymphocytes

Immunol Lett. 1998 Nov;64(1):45-7. doi: 10.1016/s0165-2478(98)00096-0.

Abstract

Chloroquine has inhibitory effects on human immunodeficiency deficiency virus (HIV)-1 replication in human lymphocytes with an ED50 of 15 microM, which approximates the chloroquine plasma concentration generated in the acute treatment of malaria. Chloroquine has a parallel inhibitory effect on DNA replication in human lymphocytes, although the inhibitory effect on DNA replication is not as pronounced as is the drug inhibition of HIV-1 replication in the cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antimalarials / blood
  • Antimalarials / pharmacology
  • Cell Division / drug effects
  • Chloroquine / blood
  • Chloroquine / pharmacology*
  • DNA / biosynthesis
  • Dose-Response Relationship, Drug
  • HIV-1 / drug effects*
  • HIV-1 / physiology
  • Humans
  • Lymphocytes / drug effects
  • Lymphocytes / virology*
  • Time Factors
  • Virus Replication / drug effects*

Substances

  • Antimalarials
  • Chloroquine
  • DNA