Estimating the rate of evolution of the rate of molecular evolution

Mol Biol Evol. 1998 Dec;15(12):1647-57. doi: 10.1093/oxfordjournals.molbev.a025892.


A simple model for the evolution of the rate of molecular evolution is presented. With a Bayesian approach, this model can serve as the basis for estimating dates of important evolutionary events even in the absence of the assumption of constant rates among evolutionary lineages. The method can be used in conjunction with any of the widely used models for nucleotide substitution or amino acid replacement. It is illustrated by analyzing a data set of rbcL protein sequences.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Algorithms
  • Biological Evolution*
  • Evolution, Molecular*
  • Models, Genetic*
  • Models, Statistical
  • Phylogeny*
  • Plant Proteins / genetics
  • Plants / classification*
  • Plants / genetics*
  • Ribulose-Bisphosphate Carboxylase*
  • Time*


  • Plant Proteins
  • RbcL protein, plastid
  • Ribulose-Bisphosphate Carboxylase