Pulse vaccination strategy in the SIR epidemic model

Bull Math Biol. 1998 Nov;60(6):1123-48. doi: 10.1006/S0092-8240(98)90005-2.


Theoretical results show that the measles 'pulse' vaccination strategy can be distinguished from the conventional strategies in leading to disease eradication at relatively low values of vaccination. Using the SIR epidemic model we showed that under a planned pulse vaccination regime the system converges to a stable solution with the number of infectious individuals equal to zero. We showed that pulse vaccination leads to epidemics eradication if certain conditions regarding the magnitude of vaccination proportion and on the period of the pulses are adhered to. Our theoretical results are confirmed by numerical simulations. The introduction of seasonal variation into the basic SIR model leads to periodic and chaotic dynamics of epidemics. We showed that under seasonal variation, in spite of the complex dynamics of the system, pulse vaccination still leads to epidemic eradication. We derived the conditions for epidemic eradication under various constraints and showed their dependence on the parameters of the epidemic. We compared effectiveness and cost of constant, pulse and mixed vaccination policies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Computer Simulation
  • Cost-Benefit Analysis
  • Humans
  • Measles / epidemiology*
  • Measles / prevention & control
  • Measles Vaccine / administration & dosage*
  • Models, Biological
  • Seasons
  • Vaccination / economics
  • Vaccination / methods*


  • Measles Vaccine