Human infections with Shiga toxin-producing Escherichia coli other than serogroup O157 in Germany

Emerg Infect Dis. Oct-Dec 1998;4(4):635-9. doi: 10.3201/eid0404.980415.

Abstract

We investigated different types of Shiga toxin-producing Escherichia coli (STEC) not belonging to serogroup O157 for their role as human pathogens. Non-O157 STEC isolated from 89 human patients in Germany were characterized according to serotypes, virulence markers, and association with human illness. EaeA-positive STEC were isolated from 54 (60.7%) of the patients and were frequently associated with severe diarrheal disease, hemolytic uremic syndrome, and young age. EaeA-negative STEC were found in 35 (39.3%) of the patients and were more associated with clinically uncomplicated cases and adult patients. For pediatric patients, a serotype-independent diagnosis of STEC is recommended.

MeSH terms

  • Adhesins, Bacterial*
  • Adolescent
  • Adult
  • Aged
  • Bacterial Outer Membrane Proteins / analysis*
  • Bacterial Outer Membrane Proteins / genetics
  • Bacterial Toxins / analysis*
  • Bacterial Toxins / genetics
  • Carrier Proteins*
  • Child
  • Child, Preschool
  • Escherichia coli / genetics
  • Escherichia coli / isolation & purification
  • Escherichia coli / pathogenicity
  • Escherichia coli Infections / microbiology*
  • Escherichia coli Infections / physiopathology*
  • Escherichia coli Proteins*
  • Female
  • Germany
  • Humans
  • Infant
  • Male
  • Middle Aged
  • Shiga Toxins
  • Virulence

Substances

  • Adhesins, Bacterial
  • Bacterial Outer Membrane Proteins
  • Bacterial Toxins
  • Carrier Proteins
  • Escherichia coli Proteins
  • Shiga Toxins
  • eaeA protein, E coli