Trypanosomiasis: an approach to chemotherapy by the inhibition of carbohydrate catabolism

Science. 1976 Oct 8;194(4261):204-6. doi: 10.1126/science.986688.

Abstract

When the infected mammalian host of Trypanosoma brucei brucei is injected with a solution of the iron chelator salicyl hydroxamic acid and glycerol, the aerobic and anaerobic glucose catabolism of the parasite is blocked and the parasite is rapidly destroyed.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cattle
  • Citric Acid Cycle / drug effects
  • Disease Models, Animal
  • Energy Metabolism / drug effects
  • Glycerol / pharmacology
  • Glycerol / therapeutic use*
  • Glycolysis / drug effects
  • Hydroxamic Acids / pharmacology
  • Hydroxamic Acids / therapeutic use*
  • Mice
  • Rats
  • Salicylamides / pharmacology
  • Salicylamides / therapeutic use*
  • Trypanosoma brucei brucei / drug effects
  • Trypanosoma brucei brucei / metabolism*
  • Trypanosomiasis, African / drug therapy
  • Trypanosomiasis, Bovine / drug therapy*

Substances

  • Hydroxamic Acids
  • Salicylamides
  • Glycerol