Effect of pH on physiology of Metarhizium anisopliae for production of swainsonine

FEMS Microbiol Lett. 1998 Nov 1;168(1):17-23. doi: 10.1111/j.1574-6968.1998.tb13249.x.


The effect of pH on the production of swainsonine and fungal morphology at different stages of fermentation of Metarhizium anisopliae was investigated. When no control was applied, the pH of the culture dropped from 6.5 to 3.8 within the first 72 hours and the concentration of swainsonine reached 43.3 mg 1(-1). When the pH was held constant either at the beginning or throughout the fermentation, the maximum recorded swainsonine level was only 8.4 mg 1(-1) corresponding with an increase in the formation of pellets. A late pH control applied after 72 hours, resulted in a swainsonine titer of 45.5 mg 1(-1).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / metabolism*
  • Bioreactors
  • Culture Media
  • Fermentation
  • Hydrogen-Ion Concentration
  • Mitosporic Fungi / metabolism
  • Mitosporic Fungi / physiology*
  • Swainsonine / metabolism*
  • Time Factors


  • Antineoplastic Agents, Phytogenic
  • Culture Media
  • Swainsonine