Effectiveness of kampo medicine (sai-boku-to) in treatment of patients with glossodynia

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998 Dec;86(6):682-6. doi: 10.1016/s1079-2104(98)90204-9.


Objective: The purpose of this study was to evaluate the usefulness of a Kampo medicine (Sai-boku-to) for treatment of patients with glossodynia.

Study design: Sai-boku-to or an antianxiety drug (diazepam) with vitamin B complex was administered orally for 3 months to each of 200 patients with glossodynia. Clinical examination evaluated the following subjective symptoms: pain, burning sensation, and discomfort. Effectiveness was evaluated as follows: "markedly effective," all 3 symptoms disappeared; "effective," pain improved; "ineffective," no improvement in pain.

Results: The effective rates were 70% after 1 month, 85% after 2 months, and 92% after 3 months of administration of Sai-boku-to (the Kampo group) and 74% after 1 month, 71% after 2 months, and 69% after 3 months of administration of the antianxiety drug with vitamin B complex (the control group). No significant side effect was noted in the Kampo group, but sleepiness was recorded in 33 cases in the control group.

Conclusions: The results indicate that Sai-boku-to may be a clinically useful medicine for the long-term treatment of patients with glossodynia.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Analysis of Variance
  • Anti-Anxiety Agents / therapeutic use
  • Chi-Square Distribution
  • Diazepam / therapeutic use
  • Drugs, Chinese Herbal / therapeutic use*
  • Female
  • Glossalgia / drug therapy*
  • Humans
  • Male
  • Medicine, Chinese Traditional*
  • Middle Aged
  • Outcome Assessment, Health Care
  • Vitamin B Complex / therapeutic use


  • Anti-Anxiety Agents
  • Drugs, Chinese Herbal
  • Vitamin B Complex
  • Diazepam