Risk of tuberculosis in dialysis patients: a population-based study

Int J Tuberc Lung Dis. 1998 Dec;2(12):989-91.


Setting: Provincial tuberculosis (TB) and dialysis registries.

Objective: To document the risk of TB among patients on dialysis and to describe the clinical characteristics of these cases.

Methods: All cases of TB occurring among dialysis patients in British Columbia between January 1990 and December 1994 were reviewed, as were the age-specific rates for TB among the general population during the same period.

Results: During that period, a total of seven cases of TB occurred among 560 patients on hemo-dialysis and two cases among 326 patients on peritoneal dialysis. On an annual basis the rate of TB in the dialysis population was 253 per 100,000, compared to an age-matched rate of 10.1 per 100,000 in the general population, giving a relative risk of 25.3 (95% confidence interval 22.86-31.49, P = 0.0000001).

Conclusions: The risk of TB in dialysis patients is significantly higher than previously reported from non population-based studies, indicating that dialysis patients should be considered a possible target population for systematic evaluation for the presence of TB infection and consideration for chemoprophylaxis.

MeSH terms

  • Adult
  • Aged
  • British Columbia / epidemiology
  • Female
  • Humans
  • Kidney Failure, Chronic / complications*
  • Male
  • Middle Aged
  • Peritoneal Dialysis*
  • Population Surveillance
  • Renal Dialysis*
  • Retrospective Studies
  • Risk Factors
  • Tuberculosis, Pulmonary / complications
  • Tuberculosis, Pulmonary / epidemiology*
  • Tuberculosis, Pulmonary / immunology