Tissue factor expression and metastatic potential of colorectal cancer

Thromb Haemost. 1998 Dec;80(6):894-8.


Several studies have previously demonstrated tissue factor (TF) expression in solid tumors. In our study, we evaluated by immunohistochemical staining TF expression in 79 cases of colorectal cancer and 17 cases of metastatic cancer of the liver from colorectal cancer, and investigated the relationship between the clinicopathological features and TF expression. TF was detected in the tumor of 57% of colorectal cancer patients, and its expression was significantly increased (p=0.01) in metastatic tumors (88%). TF expression was more commonly observed in metastatic tumors than in any Dukes' stage of primary cancer. In primary cancer, the detection of TF was more frequent in cases with lymph node metastasis (Dukes' C, 63%) or with hematogenous metastasis (Dukes' D, 82%) than in tumors without lymph node or hematogenous metastasis (Dukes' A and B, 46%, p=0.03). These results suggest that the expression of TF is related with the metastatic potential of colorectal cancer.

MeSH terms

  • Adenocarcinoma / chemistry*
  • Adenocarcinoma / pathology
  • Adenocarcinoma / secondary*
  • Adult
  • Aged
  • Biomarkers, Tumor / analysis*
  • Biomarkers, Tumor / physiology
  • Cell Differentiation
  • Colorectal Neoplasms / chemistry*
  • Colorectal Neoplasms / pathology
  • Disease Progression
  • Female
  • Humans
  • Liver Neoplasms / chemistry
  • Liver Neoplasms / secondary*
  • Lymphatic Metastasis
  • Male
  • Middle Aged
  • Neoplasm Invasiveness
  • Neoplasm Metastasis*
  • Neoplasm Proteins / analysis*
  • Neoplasm Proteins / physiology
  • Neoplastic Cells, Circulating
  • Prognosis
  • Thromboplastin / analysis*
  • Thromboplastin / physiology


  • Biomarkers, Tumor
  • Neoplasm Proteins
  • Thromboplastin