In vitro activities of six new fluoroquinolones against Brucella melitensis

Antimicrob Agents Chemother. 1999 Jan;43(1):194-5. doi: 10.1128/AAC.43.1.194.


We have tested the in vitro activities of eight fluoroquinolones against 160 Brucella melitensis strains. The most active was sitafloxacin (MIC at which 90% of the isolates are inhibited [MIC90], 0.12 microg/ml). In decreasing order, the activities (MIC90s) of the rest of the tested fluoroquinolones were as follows: levofloxacin, 0.5 microg/ml; ciprofloxacin, trovafloxacin, and moxifloxacin, 1 microg/ml; and ofloxacin, grepafloxacin, and gatifloxacin, 2 microg/ml.

Publication types

  • Comparative Study

MeSH terms

  • Anti-Infective Agents / pharmacology*
  • Brucella melitensis / drug effects*
  • Brucella melitensis / isolation & purification
  • Colony Count, Microbial
  • Fluoroquinolones


  • Anti-Infective Agents
  • Fluoroquinolones