A child with a t(11;19)(q14-21;p12) in a pulmonary mucoepidermoid carcinoma

Virchows Arch. 1998 Dec;433(6):579-81. doi: 10.1007/s004280050293.

Abstract

We report on a mucoepidermoid carcinoma (MEC) of the lung in a 6-year-old girl with a t(11;19)(q14-21;p12) as the sole karyotypic abnormality. An apparently identical t(11;19) has been reported previously in a MEC originating from the major and minor salivary glands. Our findings indicate that the t(11;19) is intimately associated with the mucoepidermoid phenotype and may be used as a diagnostic marker for this tumour type.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biomarkers, Tumor
  • Carcinoma, Mucoepidermoid / genetics*
  • Carcinoma, Mucoepidermoid / metabolism
  • Carcinoma, Mucoepidermoid / pathology
  • Child
  • Chromosomes, Human, Pair 11
  • Chromosomes, Human, Pair 19
  • Female
  • Humans
  • Immunohistochemistry
  • Karyotyping
  • Lung Neoplasms / genetics*
  • Lung Neoplasms / metabolism
  • Lung Neoplasms / pathology
  • Translocation, Genetic*

Substances

  • Biomarkers, Tumor