Amygdalin binds to the CD4 receptor as suggested from molecular modeling studies

Bioorg Med Chem Lett. 1998 Apr 7;8(7):781-6. doi: 10.1016/s0960-894x(98)00120-6.

Abstract

The geometrical features of the proposed bioactive conformation of peptide T assessed by computational methods in a previous study, together with available structure-activity studies on peptide T, led us to propose a pharmacophore for the CD4-peptide T interaction. Subsequent, data base searching permitted us to identify amygdalin as a peptide T peptidomimetic.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amygdalin / chemistry*
  • Amygdalin / metabolism*
  • Binding Sites
  • CD4 Antigens / chemistry*
  • CD4 Antigens / metabolism*
  • Chemotaxis, Leukocyte
  • Humans
  • In Vitro Techniques
  • Leukocytes, Mononuclear / immunology
  • Leukocytes, Mononuclear / physiology*
  • Models, Molecular
  • Peptide T / analogs & derivatives
  • Peptide T / chemistry*
  • Peptide T / metabolism*
  • Protein Conformation*

Substances

  • CD4 Antigens
  • Peptide T
  • Amygdalin