A depsipeptide fungal metabolite inhibitor of cholesteryl ester transfer protein

V R Hegde; P Dai; M Patel; P R Das; S Wang; M S Puar

doi:10.1016/s0960-894x(98)00224-8

A depsipeptide fungal metabolite inhibitor of cholesteryl ester transfer protein

Bioorg Med Chem Lett. 1998 Jun 2;8(11):1277-80. doi: 10.1016/s0960-894x(98)00224-8.

Authors

V R Hegde¹, P Dai, M Patel, P R Das, S Wang, M S Puar

Affiliation

¹ Schering Plough Research Institute, Kenilworth, NJ 07033, USA.

PMID: 9871749
DOI: 10.1016/s0960-894x(98)00224-8

Abstract

The organic extract of the fermentation broth of a fungus was found to contain a depsipeptide SCH 58149 (1), containing three amino acids and a beta-hydroxy acid, by spectroscopic studies. The amino acids were phenyl alanine, alanine and leucine and the beta-hydroxy acid is 3-hydroxy-4-methyl octanoic acid. SCH 58149 exhibited weak activity against cholesterol ester transfer protein (CETP) with an IC50 of 50 microM.

MeSH terms

Acremonium / metabolism*
Amino Acids / analysis
Carrier Proteins / antagonists & inhibitors*
Cholesterol Ester Transfer Proteins
Cholesterol Esters / metabolism*
Depsipeptides*
Fermentation
Glycoproteins*
Magnetic Resonance Spectroscopy
Peptides, Cyclic / analysis
Peptides, Cyclic / isolation & purification
Peptides, Cyclic / pharmacology*
Spectrometry, Mass, Fast Atom Bombardment
Spectrophotometry, Ultraviolet

Substances

Amino Acids
Carrier Proteins
Cholesterol Ester Transfer Proteins
Cholesterol Esters
Depsipeptides
Glycoproteins
Peptides, Cyclic
SCH 58149