The Nck SH2/SH3 adaptor protein: a regulator of multiple intracellular signal transduction events

Bioessays. 1998 Nov;20(11):913-21. doi: 10.1002/(SICI)1521-1878(199811)20:11<913::AID-BIES6>3.0.CO;2-T.


The process generally termed signal transduction involves the coordinated relay of information from extracellular cues to intracellular effectors, subsequently leading to a specified cellular response. The formation of multimeric protein complexes is a critical step in the activation of most intracellular signal transduction cascades. In many cases, these processes are initiated by a family of molecules consisting of protein association motifs known as src homology 2 and 3 (SH2 and SH3) domains. This review focuses on a group of proteins within this family that lack intrinsic enzymatic functions and consist almost entirely of SH2 and SH3 domains. Termed "adaptors," these proteins serve to physically bridge activated cell surface receptors to various intracellular signal transduction pathways. Here, I briefly summarize current knowledge concerning the various adaptor proteins and place a particular emphasis on Nck. Various data are discussed which collectively support a role for Nck in the regulation of multiple intracellular signaling events.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing*
  • Animals
  • Cell Division
  • ErbB Receptors / metabolism
  • GRB2 Adaptor Protein
  • Humans
  • Models, Biological
  • Oncogene Protein v-crk
  • Oncogene Proteins / chemistry
  • Oncogene Proteins / genetics
  • Oncogene Proteins / metabolism*
  • Phosphatidylinositol 3-Kinases / metabolism
  • Proteins / chemistry
  • Proteins / metabolism
  • Retroviridae Proteins, Oncogenic / chemistry
  • Retroviridae Proteins, Oncogenic / metabolism
  • Signal Transduction*
  • src Homology Domains*


  • Adaptor Proteins, Signal Transducing
  • GRB2 Adaptor Protein
  • GRB2 protein, human
  • Nck protein
  • Oncogene Protein v-crk
  • Oncogene Proteins
  • Proteins
  • Retroviridae Proteins, Oncogenic
  • Phosphatidylinositol 3-Kinases
  • ErbB Receptors