Neuronorm is a potent and water soluble neurokinin A receptor antagonist

Bioorg Med Chem Lett. 1998 Jul 7;8(13):1735-40. doi: 10.1016/s0960-894x(98)00282-0.


We report here the synthesis and preliminary pharmacological characterization of a novel water soluble Neurokinin A receptor antagonist named Neuronorm. The synthesis was achieved in high yield by a combination of classical peptide synthesis methodologies, in both solution and solid phase. The pharmacological properties as neurokinin A receptor antagonist were assessed in in vitro experiments on rat vas deferens and guinea pig trachea, and were compared to those of MEN10627.

MeSH terms

  • Animals
  • Guinea Pigs
  • In Vitro Techniques
  • Male
  • Peptides, Cyclic / chemical synthesis
  • Peptides, Cyclic / pharmacology*
  • Rats
  • Receptors, Neurokinin-2 / antagonists & inhibitors*
  • Trachea / drug effects
  • Vas Deferens / drug effects


  • Peptides, Cyclic
  • Receptors, Neurokinin-2
  • neuronorm
  • MEN 10627